Peripheral Amyloid-β Levels Regulate Amyloid-β Clearance from the Central Nervous System
نویسندگان
چکیده
منابع مشابه
Human apoE isoforms differentially regulate brain amyloid-β peptide clearance.
The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late-onset, sporadic Alzheimer's disease (AD). The APOE ε4 allele markedly increases AD risk and decreases age of onset, likely through its strong effect on the accumulation of amyloid-β (Aβ) peptide. In contrast, the APOE ε2 allele appears to decrease AD risk. Most rare, early-onset forms of familial AD are caused b...
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Cerebral amyloid angiopathy (CAA), the accumulation of β-amyloid (Aβ) peptides in the walls of cerebral blood vessels, is observed in the majority of Alzheimer's disease (AD) brains and is thought to be due to a failure of the aging brain to clear Aβ. Perivascular drainage of Aβ along cerebrovascular basement membranes (CVBMs) is one of the mechanisms by which Aβ is removed from the brain. CVBM...
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ژورنال
عنوان ژورنال: Journal of Alzheimer's Disease
سال: 2009
ISSN: 1875-8908,1387-2877
DOI: 10.3233/jad-2009-0964